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Publication list

  • Breuer, T., Tibbe, C., Troost, T. and Klein, T. (2024). Structural Analysis of the ESCRT-III Regulator Lethal(2) Giant Discs/Coiled-Coil and C2 Domain-Containing Protein 1 (Lgd/CC2D1). Cells, 13, doi.org/10.3390/cells13141174
  • Cao, R., Gozlan, O., Airich, A., Tveriakhina, L., Zhou, H. , Jiang, H., Cole, P. A., Aster, J. C., Klein, T., Sprinzak, D. and Blacklow, S. J. (2024). Structural Requirements for Activity of Mind bomb1 in Notch Signaling. Structure, in press.
  • Troost, T., Seib, E., Airich, A., Vüllings, N., Necakov, A., De Renzis, S. and Klein, T. (2023). The meaning of ubiquitylation of the DSL ligand Delta for the development of Drosophila. BMC Biology, DOI: 10.1186/s12915-023-01759-z
  • Kalodimou, K., Stapountzi, M., Vüllings, N., Seib, E., Klein, T. and Delidakis, C. (2023). Separable roles for Neur and ubiquitin in Delta signalling in the Drosophila CNS lineages. Cells, DOI: 10.3390/cells12242833.
  • Troost, T., Binshtok, U., Sprinzak, D. and Klein, T. (2023). Cis-inhibition suppresses basal Notch signalling during sensory organ precursor Selection. PNAS, 120. doi: 10.1073/pnas.2214535120.
  • Baeumers, M. Schulz, K. and Klein, T. (2022). Using Drosophila melanogaster to analyse the human paralogs of the ESCRT-III core component Shrub/CHMP4/Snf7 and its interactions with members of the LGD/CC2D1 family. Int. J. Mol. Sci., doi: 10.3390/ijms23147507
  • Schnute, B., Shimizu, H. Baron, M. and Klein, T. (2022). Ubiquitylation is required for the incorporation of the Notch receptor into intraluminal vesicles to prevent prolonged and ligand-independent activation of the pathway. BMC Biology, doi: 10.1186/s12915-022-01245-y.
  • Pannen, H., Rapp, T. and Klein, T. (2020). The ESCRT machinery regulates retromer-dependent transcytosis of septate junction components in Drosophila. Elife, doi: 10.7554/eLife.61866.
  • Baeumers, M., Ruhnau, K., Breuer, T., Pannen, H., Goerlich, B., Kniebel, A. Haensch, S., Weidtkamp-Peters, S., Schmitt, L. and Klein, T. (2020). Lethal (2) giant discs (Lgd)/CC2D1 is required for the full activity of the ESCRT machinery. BMC Biology, doi: 10.1186/s12915-020-00933-x.
  • Bäumers, M., Klose, S., Brüser, C., ,Haag, C., Hänsch, S., Pannen, H., Weidtkamp-Peters, S., Feldbrügge, M. and Klein, T. (2019). The auxiliary ESCRT complexes provide robustness to cold in poikilothermic organisms. Biol Open, doi: 10.1242/bio.043422.
  • Berndt, N., Seib, E, Kim, S., Troost, T., Lyga,M., Langenbach, J., Haensch, S. Kalodimou, K., Delidakis,C. and Thomas Klein (2017). Ubiquitylation-independent activation of Notch signalling by Delta. Elife. 2017 Sep 29;6. pii: e27346. doi: 10.7554/eLife.27346 IF: 7,725
  • McMillan, B., Tibbe, C., Drabek, A., Seegar, T., Blacklow, S. and Klein, T. (2017). Structural basis for regulation of ESCRT-III complexes by Lgd. Cell Rep., 19:1750-1757, IF: 7.8
  • McMillan, B. J., Tibbe, C., Jeon, H., Klein, T. and Blacklow, S. C. (2016). Electrostatic interactions between elongated monomers drive filamentation of Drosophila Shrub, a metazoan ESCRT-III protein. Cell Rep., 16: 1211-1217, IF: 7.8
  • Drusenheimer,N. Migdal, B., Jäckel, S., Tveriakhina, L., Scheider, K., Schulz, K., Gröper, j., Köhrer, K. and Klein, T. (2015). The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling, PLoS Genetics, IF: 7, 53
  • Gomez-Lamarca, M., Snowdon, L., Seib, E., Klein, T. and Bray, S. B. (2015). Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signalling. JCB, 210: 303-318, IF: 9,83
  • Morawa, K. S., Schneider, M. and Klein, T. (2015). Lgd regulates the activity of the BMP/Dpp signalling pathway during Drosophila oogenesis. Development, 142: 1325-1335,  IF: 6, 46
  • McMillan, B., Schnute, B., Ohlenhard, N., Zimmerman, B., Miles, L., Beglove, N., Klein, T. and Blacklow, S. (2015). A Tail of Two Sites: A Bipartite Mechanism for Recognition of Notch Ligands by Mind Bomb E3 Ligases. Molecular Cell, 57: 912-924, IF: 14, 01
  • Troost, T., Schneider, M. und Klein, T. (2015). A re-examination of the selection of the sensory organ precursor of the bristle sensilla of Drosophila melanogaster. PLoS Genetics, IF: 7, 53
  • Yousefian J, Troost T, Grawe F, Sasamura T, Fortini M, Klein T. (2013). Dmon1 controls recruitment of Rab7 to maturing endosomes in Drosophila. J. Cell Sci. 126: 1583-94, IF: 6, 0
  • Schneider, M., Troost, T.,  Grawe, F., Martinez-Arias, A and Klein, T. (2012).  Activation of Notch in lgd mutant cells requires the fusion of late endosomes with the lysosome. JCS, 126, 645-56, IF: 6, 0
  • Troost, T. and Klein, T. (2012). Sequential Notch Signalling at the Boundary of Fringe expressing and Non-expressing cells. PLoS One, 7, IF: 3, 7
  • Troost, T, Jäckel, S. Ohlenhard, N. and Klein, T. (2012). The tumor suppressor Lethal (2) giant discs (Lgd) is required for the function of the ESCRT-III component Shrub/CHMP4. JCS, 125, 763-776, IF: 6, 0
  • Fiuza, U-M., Klein, T. Martinez-Arias, A. und Hayward, P. (2010). Mechanisms of ligand mediated inhibition in Notch signaling activity in Drosophila, Dev. Dyn., 798-805, IF: 2,37
  • Kaspar, M., Schneider, M. Chia, W. und Klein, T. (2008). Klumpfuss is involved in the determination of sensory organ precursors in Drosophila. Dev. Biol. 324, 177-191, IF: 3, 5
  • Geffers, I., Serth, K., Chapman, G., Jaeckel, R., Schuster-Gossler, K., Cordes, R., Kremmer, E., Dunwoodie, S., Klein, T., and Gossler, A. (2007). Divergent functions and localization of the mouse DLL1 and DLL3 proteins in vivo. JCB 178, 465-476, IF: 9,83
  • Jaekel, R. and Klein, T. (2006). The Drosophila Notch Inhibitor and Tumour Suppressor Gene lethal (2) giant discs Encodes a Conserved Regulator of endosomal trafficking. Dev. Cell, 11, 655-669, IF: 9, 7
  • Kaspar, M. and Klein, T. (2006). Functional analysis of murine CBF1 during Drosophila development.  Dev Dyn  9, 18-27, IF: 2,37
  • Kölzer, S. und Klein, T. (2006). Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless. Dev Biol 289, 77-90. IF: 3, 5
  • Kölzer. S, Fuss, B., Hoch, M. und Klein, T. (2003). The homeobox transcription factor encoded by the defective ventriculus (dve) gene is required for pattern formation   along the proximo-distal axis, cell proliferation and formation of veins in the Drosophila wing. Development 130, 4135-4147, IF: 6, 46
  • Kölzer, S. und Klein, T. (2003). A Notch independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila. Development 130, 1973-1988. IF: 6, 46
  • Klein, T. (2003). The tumour suppressor gene l(2)giant discs is required to restrict the activity of Notch to the dorso-ventral boundary during Drosophila wing development. Dev. Biol. 255, 313-333. IF: 3, 5
  • Klein, T. (2002). kuzbanian is required cell autonomously during Notch signalling in the Drosophila wing. Dev. Genes Evol. 212, 251-255, IF: 2, 44
  • Klein,T., Seugnet, L., Haenlin, M. and Martinez-Arias, A. (2000).Two different activities of Suppressor of Hairless during wing development in Drosophila. Development 127, 3553-3579, IF: 6, 46
  • Lawrence, N*, Klein, T*., Brennan, K*, and Martinez Arias, A. (2000)Structural requirements for Notch signalling with Delta and Serrate duringthe development and patterning of the wing disc of Drosophila. Development 127, 3185-3195, (*gleicher Beitrag der Autoren), IF: 6, 46
  • Brennan, K., Klein, T., Wilder, E. and Martinez-Arias, A. (1999). Wingless modulates the effects of dominant negative Notch molecules in the developing wing of Drosophila. Implications for Notch and Wingless signalling. Dev. Biol. 216, 210-229, IF: 3, 5
  • Bishop, S.A., Klein, T., Martinez-Arias, A. and Couso, J.P. (1999). Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch. Development  126, 2993-3003, IF: 6, 46
  • Klein, T. and Martinez-Arias, A. (1999). The Vestigial gene product provides amolecular context for the interpretation of signals during the development of the wing in Drosophila. Development  126, 913-925, IF: 6, 46
  • Klein, T. and Martinez-Arias, A. (1998b). Interactions among Delta, Serrate and Fringe modulate Notch activity during Drosophila wing development. Development  125, 2951-2962, IF: 6, 46
  • Klein, T., Couso, J.P. and Martinez-Arias, A. (1998a). Wing development and specification of dorsal cell fates in the absence of apterous in Drosophila.. Current Biology, 8, 417-420, IF: 9,57
  • Klein, T. and Martinez-Arias, A. (1998a). Different spatial and temporal interactions       between Notch, wingless and vestigial  specify proximal and distal pattern elements of the wing in Drosophila. Bei Dev. Biol. 194, 196-212, IF: 3, 5
  • Klein, T. und Campos-Ortega, J.A. (1997). klumpfuss. a Drosophila  gene encoding a member of the EGR family of transcription factors, is involved in bristle and leg development. Development  124, 3123-3134 IF: 6, 46
  • Yang, X., Bahri, S., Klein, T. und Chia, W. (1997). klumpfuss, a putative EGR-1 family transcription regulator, acts to differentiate between the identities of two secondary progenitor cells within one neuroblast lineage. Genes Dev. 11, 1396-1408, IF: 12, 64
  • Klein, T., Brennan, K. und Martinez-Arias (1997). An intrinsic dominant negative activity of Serrate that is modulated by wingless . Dev. Biol. 189, 123-134 IF: 3, 5
  • Klein, T. (1994). Genetische und molekulare Charakterisierung des Gens klumpfuß von Drosophila melanogaster. Inaugural-Dissertation zur Erlangung des Doktorgrades der Math.-Nat. Fak. der Universität Köln
  • Hart, K., Klein, T. und Wilcox, M. (1993). A minute encoding a ribosomal protein enhances wing morphogenesis mutants. Mech. Dev. 43, 101-110 IP: 2,44
  • Klein, T. und Campos-Ortega, J. A. (1992). Second-site modifier of the Delta wing phenotype in Drosophila melanogaster. Roux's Arch. Dev. Biol. 202, 49-60 IP: 0
  • Klein, T. und Briegleb, W. (1988). Bau, Funktion und Leistung des Vestibularsystems: Vergleich von Wasser-und Landvertebraten, Institut für Flugmedizin, DLR, IB 316-88-03

Reviews/Bookchapters

  • Seib, E. and Klein, T. (2021). The role of Ligand endocytosis in Notch signaling. Biol Cell, doi: 10.1111/boc.202100009.

  • Reiff, T., Baeumers, M., Tibbe, C., Klein, T. (2021) Unraveling of Hidden Secrets: The Tumour Suppressor Lethal (2) Giant Discs (Lgd)/CC2D1, Notch Signaling and Cancer. In: Reichrath J, Reichrath S (eds) Notch signaling in embryology and cancer: Notch Signaling in Cancer. Adv Exp Med Biol, 1287, 31-46.

  • Haag, C., Klein, T. and Feldbrügge, M. (2019). Functional in vivo analysis of ESCRT components using model fungi. Book chapter for The ESCRT Complex: Methods and Protocols – Methods in Molecular Biology, Editors Emmanuel Culetto and Renaud Legouis

  • Schnute, B. Troost, T. and Klein, T. (2018). Endocytic Trafficking of the Notch Receptor. Adv Exp Med Biol. 1066:99-112, doi: 10.1007/978-3-319-89512-3_6.

  • Klein, T. (2007). Immunolabelling of Imaginal discs. In Methods in Molecular Biology, Volume: Drosophila, ed. Christian Dahmann, Humana Press.

  • Klein, T. (2004). Notch-pathway. Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer-Verlag, siehe: http://encref.springer.de/genomics

  • Klein, T. (2001). Wing disc development in the fly: The early stages. Curr. Opinion Gen. & Dev. 11, 470-475, IF: 7, 58