www.genetics.hhu.de/forschung-ag-reiff

Hyperactivation of the Wnt pathway initiates the formation of colonic adenomas preceeding colorectal carcinomas (CRCs), while estrogen receptor signaling has a protective role in CRC development. In my project I am characterizing the functions of a transcription factor possibly linking estrogen related ecdysone signaling and local Wnt signaling in ISC physiology and pathology in Drosophila to get insights into the mechanisms by which steroid hormones may modulate Wnt signaling in CRC.